Lipid Peroxidation in Alzheimer’s Disease

Discussing the FRBM issue 'Lipid Peroxidation in Alzheimer's Disease' written by D. Allan Butterfield.

Speaker: Prof. D. Allan Butterfield, University of Kentucky, USA
Moderator: Prof. Jose Vina, Universidad de Valencia, Spain

Prof. D. Allan Butterfield is the Alumni Association Endowed Professor of Biological Chemistry; Associate Vice President for Research for Centers and Institutes and for RPAs; Director of the Redox Metabolism Shared Resource Facility; Interim Executive Director of Tracy Farmer Institute for Sustainability and the Environment; and Research Professor at the University of Kentucky.

• [0:25] Introduction of Dr. Butterfield
• [4:00] How Dr. Butterfield's maintained his early career
• [12:30] The source of peroxides in the neuronal membranes
• [16:13] The relevance of lipid oxidation in brain activity
• [24:30] How Dr. Butterfield's work in redox proteomics helps us to understand the role of specific proteins in the development of Alzheimer's pathology
• [37:03] Why metabolic disorders have such a major risk factor for the development of dementia
• [42:30] How down syndrome is a model of Alzheimer's
• [47:50] Dr. Butterfield's thoughts on future antioxidant strategies in the prevention and treatment of Alzheimer's & new therapeutic approaches
• [55:00] Advice for young people pursuing science and medicine as a career