#51: citalopram (Celexa) | Treats Major Depressive & Obsessive Compulsive Disorder

Citalopram is also known by the brand name Celexa. It is an antidepressant and a selective serotonin reuptake inhibitor (SSRI). The tablet come in a 10 mg, 20 mg, and 40 mg strength and is also available as a 10 mg/5 ml solution. In adults and pediatrics it can be used to treat both major depressive and obsessive compulsive disorder. There are other off-label indications in children but the only approved use is in adults for major depressive disorder. The treatment range for treating major depressive disorder in adults is 20-40 mg PO qd with a max of 40 mg/day. There is literature with a max of 60 mg/day for OCD but 40 mg/day is the most commonly accepted max dose. The onset of action and benefits for patients are typically seen within the first 1-2 weeks with continued improvements through weeks 4-6. The medication half-life is around 24-48 hours with a duration of action being the same. There is a black box warning for suicidality with the greatest concern for children, adolescents and young adults. The risk does appear to decrease in adults >24 years of age and in the elderly >65 years of age. The medication should never be stopped without approval from the prescriber even when feeling well.

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