#08 Nir Barziali | Metformin, TAME Trial & Centenarian Longevity Research

Dr. Nir Barzilai is well-known in the field of longevity and beyond and is the director and chair of several institutes focused on Aging research. Just to name a few, he is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging.

Dr. Barzilai’s research interests are in the biology and genetics of aging, so he has done extensive work studying centenarians and supercentenarians some of which he discusses in today’s episode and also in his book Age Later.

He is currently leading an international effort to approve drugs that can target aging. Targeting Aging with METformin (TAME) is a specific study designed to prove the concept that multi-morbidities of aging can be delayed by metformin, working with the FDA to approve this approach which will serve as a template for future efforts to delay aging and its diseases in humans.

In today's episode, we discuss centenarian longevity genes, what makes centenarians live so long and the role of growth hormones in longevity. We also dive into metformin's healthspan benefits for longevity, metformin & COVID, if metformin blunts muscle mass and causes hypoglycemia, and metformin dosage.

Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/snbarzilai

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