Drake London attended Moorpark High School in Moorpark, California. He played football and basketball in high school. As a senior on the football team, he had 62 receptions for 1,089 yards and 12 touchdowns. Upon completion of High School, Drake London committed to the University of Southern California (USC) to play both college football and college basketball.
London appeared in 22 games for the Trojans over three seasons. In those 22 contests, London totaled 2,153 yards on 160 career receptions. London found the end zone a total of 15 times at USC. His best season came in his 2021 junior season in which he totaled 1,086 scrimmage yards, and scored 7 times. London has his junior season cut short after breaking his ankle in late October in a game against the Arizona Wildcats. Despite the injury, Drake still won the PAC-12 offensive player of the year, an honor that never has gone to a player who missed as much of a season as London.