Dexmedetomidine Pharmacology

Dexmedetomidine is a selective alpha-2-adrenergic agonist with sedative characteristics.

Dexmedetomidine is commonly used in ICU and procedural sedation, as well as postoperative pain.

A few of the more serious adverse effects of dexmedetomidine to keep an eye on including bradyarrhythmias/bradycardia and hypotension.

Dexmedetomidine undergoes hepatic metabolism, meaning a dose reduction may be required in patients with impaired hepatic function.

Major drug interactions to monitoring for with dexmedetomidine include co-administration with anesthetics, sedatives, hypnotics, and opioids, as it may lead to an enhancement of effects.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

It is also important to note that dexmedetomidine may produce withdrawal symptoms if used for longer than 24 hours.

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