Unravelling the mysteries of the vasculature in muscle with Dr Katrien de Bock

Dr Glenn McConell chats with Professor Katrien de Bock from ETH Zürich - Swiss Federal Institute of Technology. We discussed how exercise training increases blood vessels in skeletal muscle. Also muscle cells and blood vessels in regards to injury/repair and cancer. We also discussed exercise and leucine sensitivity.

0:00. Introduction

2:00. What is the vasculature. Blood vessels Endothelial cells etc

5:46. Redirecting blood to the muscle during exercise

7:16. Exercise training increases blood vessels in muscle

8:50. Exercise also improves blood vessel function

10:13. How does exercise increase muscle blood vessels? Called angiogenesis. It appears there is either sprouting or splitting into two. Not clear still.

14:32. Does every study you do work? Need resilience. “Negative data”.

19:06. Types of cells in blood vessels/ cell cross talk Satellite cells, white blood cells etc.

21:05. Muscle repair and blood vessel cells Timing important. Anti inflammatories

24:20. Too many anti inflammatories not ideal For adaptations to exercise and muscle repair.

24:44. Exercise blood flow stimulates blood vessel growth/angiogenesis Also vascular endothelial growth factor.

27:07. Hypoxia inducible factor 1 alpha (HIF1a) Exercise is an adaptive response to stress 29:28. Endothelial cells differ between organs The experimental models that she uses. Metabolically active endothelial cells.

33.17. Different types of exercise and blood vessel growth

35:35. Blood vessels and satellite cells

37:30. The importance of cell, animal and human studies

38:35. Keep eyes open to collaborations from left field Serendipity and persistence. Apold1.

43:07. Blood flow restriction/iliac artery endofibrosis

46:27. Exercise and leucine sensitivity Timing of protein intake after exercise not important. Anabolic resistance.

50:45. Takeaway messages

52:40. Exercise, cancer and blood vessels etc

54:34. Outro (9 seconds)

Inside Exercise brings to you the who's who of exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.

The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.

He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).

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