Why would someone not tolerate methyl donors even if they need them? | Masterjohn Q&A Files #306
Short Answer: I believe most methyl donor intolerances are a result of deficiencies in the glycine buffer system, which requires glycine, vitamin A, fasting (glucagon), androgens, riboflavin, unmethylated folate (THF), and iron. No one should expect to tolerate 30 milligrams of folate, however, and there is almost never a reason to use doses that high.
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This snippet is from the September 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:
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