An integrated RNA-proteomic landscape of drug induced senescence in a cancer cell line

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.21.533605v1?rss=1 Authors: Görtler, F., Al-Roshdi, M., Grellscheid, S. N., Stevenson, T. Abstract: Senescent cells are characterized by an arrest in proliferation. In addition to replicative senescence resulting from telomere exhaustion, sub-lethal genotoxic stress resulting from DNA damage, oncogene activation, mitochondrial dysfunction or reactive metabolites also elicits a senescence phenotype. Senescence is a controlled programme affecting a wide variety of biological processes with some core hallmarks of senescence as well as tissue specific changes. This study presents an integrative multi-omic analysis of proteomic and RNA-seq from proliferating and senescent osteosarcoma cells. This study demonstrates senescence induction in a widely used cell line which can be used as a model system for characterising cancer cell responses to sub-lethal doses of chemotherapeutic agents, and makes available both RNA-seq and proteomic data from proliferating and senescent cells in open access repositories to aid reuse by the community. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC