Sounds Like Comics Ep 209 - Blade: Trinity (Movie 2004)

Written and directed by David S. Goyer, Blade: Trinity is the 2004 superhero film based on the Marvel Comics character of the same name. Luke and Jae return to the final hunt as Wesley Snipes reprises his role as Blade. The war between humans and vampires continues, but the humans' best hope, human-vampire hybrid warrior Blade (Wesley Snipes), has been framed for countless murders, turning popular sentiment against him. The vampire leader responsible for Blade's bad publicity is Danica Talos (Parker Posey), who's determined to finally lead her bloodthirsty compatriots to victory. Now Blade must team up with a band of rogue vampire hunters (Ryan Reynolds, Jessica Biel) to save humanity.