Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2023.04.04.535547v1?rss=1
Authors: Adamo, G., Santonicola, P., Picciotto, S., Gargano, P., Nicosia, A., Longo, V., Aloi, N., Romancino, D. P., Paterna, A., Rao, E., Raccosta, S., Noto, R., Salamone, M., Costa, S., Alfano, C., Zampi, G., Colombo, P., Wei, M., Touzet, N., Manno, M., Di Schiavi, E., Bongiovanni, A.
Abstract:
Nanoalgosomes are extracellular vesicles (EVs) released by microalgal cells that can mediate intercellular and cross-kingdom communication. In the present study, the optimization of high quality nanoalgosome manufacturing from cultures of the marine microalgae Tetraselmis chuii has been enhanced by quality control procedures, applying robust biophysical and biochemical characterizations. Then, we evaluated the biological properties of nanoalgosomes in pre-clinical models. Our investigation of nanoalgosome biocompatibility included toxicological and genetic analyses, starting from studies on the invertebrate model organism Caenorhabditis elegans and proceeding to hematological and immunological evaluations in mice and human cells. Nanoalgosome biodistribution was evaluated in mice with accurate space-time resolution, and in C. elegans at cellular and subcellular levels. Further examination highlighted the antioxidant and anti-inflammatory bioactivities of nanoalgosomes. This holistic approach to nanoalgosome characterization showcases that nanoalgosomes are innate effectors for novel cosmetic formulations and EV-based therapies.
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