Episode 269 - Systematic Review: Which Intervention Will Help Improve Muscle Mass?

This week I discuss a systematic review and meta analysis looking at 10 pharmacological interventions to help with sarcopenia (muscle loss) as we age. 

The 10 interventions were: Vitamin D, combined estrogen-progesterone, dehydroepiandrosterone, growth hormone, growth hormone-releasing hormone, combined testosterone-growth hormone, insulin-like growth factor-1, pioglitazone, testosterone and angiotensin-converting enzyme inhibitors.

The two winners were: Vitamin D had a significant effect on muscle strength and physical performance, especially in women with low baseline values (< 25 nmol/l). Testosterone had a strong effect on muscle mass and a modest to minimal effect on muscle strength and physical performance, respectively, when supplementing men with low serum levels (< 200-300 ng/dl). 

So to conclude: Vitamin D, especially in older women, and testosterone in older men with clinical muscle weakness and low testosterone serum levels can be justified in daily clinical practice to improve muscle mass, muscle strength and/or physical performance.

Make sure to get your levels checked and make sure you are in optimal range:

- Optimal values for Vitamin D are between 50 and 70 ng/mL. 

- Sufficient Values for Testosterone are between 300 - 1000 ng/dL

Have a great day!

Citation:

De Spiegeleer A, Beckwée D, Bautmans I, Petrovic M; Sarcopenia Guidelines Development group of the Belgian Society of Gerontology and Geriatrics (BSGG). Pharmacological Interventions to Improve Muscle Mass, Muscle Strength and Physical Performance in Older People: An Umbrella Review of Systematic Reviews and Meta-analyses. Drugs Aging. 2018 Aug;35(8):719-734. doi: 10.1007/s40266-018-0566-y. PMID: 30047068.

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