Positive feedback regulation of Pparγ1sv and Pparγ2 during adipogenesis in 3T3-L1 cells

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.03.551916v1?rss=1 Authors: Takenaka, Y., Kakinuma, Y., Inoue, I. Abstract: We have previously identified the novel splicing variant of mouse Ppar{gamma} (Ppar{gamma}1sv) and proposed the synergistic regulation of the early stage of adipocyte differentiation by Ppar{gamma}1sv and Ppar{gamma}2. Here, we report the finding of PPAR{gamma}-binding sites within the Ppar{gamma} gene locus and its importance in adipogenesis and propose the positive feedback regulation of Ppar{gamma}1sv and Ppar{gamma}2 expression during the adipocyte differentiation of 3T3-L1 cells. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC