326. How Epigenetics Drive Your DNA feat. Nessa Carey

The double helix of DNA twists in the heart of every human cell, and it comes with some editing software known as epigenetics that power what parts turn on and off and when. Scientists are still still working to understand exactly how genetics and epigenetics work, but we are learning more every day.

Nessa Carey is the former International Director at PraxisUnico and the author of several books on genetics. Her latest book is titled Hacking the Code of Life: How gene editing will rewrite our futures.

Nessa and Greg discuss how genetics and epigenetics work and are related, with some concrete examples. Nessa discusses how genetics have been used to clone species and cells in laboratories and the differences between other animals and humans. Greg and Nessa talk about the uses and limitations of gene technology and the exciting possibilities of the gene editing technology CRISPR.

*unSILOed Podcast is produced by University FM.*

Episode Quotes:

Not all scientists are the same

01:00:39: We have to get better at recognizing that not all scientists are the same. Some are really good problem solvers, some are really good creative thinkers, and it's about finding the right ways to support those people to maximum effect. And we need both. We need the problem solvers as well as the genuinely, deeply creative people. And that is expensive, but on the other hand, you don't get the great breakthroughs. If we only had the problem solvers, all we would have now are better iron lungs for polio. We'd never have a vaccine. But sometimes you need those problem solvers to get other things done as well. So we need to be supporting all different types of research.

On the complexity of biology

17:27: The reality is biology is very, very complicated. All of those systems need to work. If any of them fall apart, the whole thing falls apart. But we're surprisingly tribal and surprisingly wedded to our own theories. I think in biology, we quite often don't realize we're constantly putting ourselves on Gartner's hype cycle, and everybody gets very invested in whichever bit they like and where it's in the cycle at the time.

The beauty and cultural value of funding science

01:01:52: It's a mistake to think we should fund science because, eventually, it'll fund us back. We should fund science because it's beautiful. We should fund it because it's a magnificent cultural activity that adds to the wealth of human gorgeousness in the same way that fine arts and great literature do. Stuff shouldn't just be funded because it has an economic imperative. Isn't it just beautiful to understand more about how the world works?

Why is epigenetics a notable example of scientific paradigm shifts?

14:49: Epigenetics has been a great example of how you get paradigm shifts in scientific fields. You get this situation where there's the prevailing theory, and it survives a lot of onslaughts. But then eventually, it crumbles, and the new theory emerges. So, it's been great both scientifically and in terms of the philosophy of science.

Show Links:Recommended Resources:

• Waddington Landscape
• The Emperor of All Maladies: A Biography of Cancer
• Gartner Hype Cycle
• John Gurdon and Shinya Yamanaka’s Work
• Anne Ferguson-Smith

Guest Profile:

• Profile on The Royal Society
• Nessa Carey's Website
• Nessa Carey on LinkedIn
• Nessa Carey on X

Her Work:

• Hacking the Code of Life: How gene editing will rewrite our futures
• The Epigenetics Revolution: How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance
• Junk DNA: A Journey Through the Dark Matter of the Genome
• Huffington Post Articles