#319: What is Epidermal Necrolysis?

Epidermal necrolysis refers to severe cutaneous reactions that cause extensive necrosis of tissue and detachment of the epidermis. It encompasses three conditions which are on a continuum of severity and how much of the body’s surface area is affected:

• Stevens-Johnson syndrome (SJS): Less than 10% of BSA is detached
• Toxic epidermal necrolysis (TEN) - More than 30% of BSA is detached
• SJS/TEN overlap: Between 10 and 30% of BSA is detached

In this episode you’ll learn: 

• Epidermal necrolysis pathophysiology and risk factors
• High risk medications that can cause SJS/TEN
• Complications of SJS/TEN
• Signs and symptoms in the prodromal and acute phase
• Important assessment for a patient with SJS/TEN
• Key tests utilized to diagnose and evaluate a patient with epidermal necrolysis
• Treatments for SJS/TEN, including medications
• Vital education components for patients and families

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