Episode 9567: "The Ralph Kramden Coeporation" (The Honeymooners)

The Honeymooners first was featured on Cavalcade of Stars on October 5, 1951, with Carney in a guest appearance as a cop (Norton did not appear until a few episodes later) and character actress Pert Kelton as Alice. Darker and fiercer than the milder later version with Audrey Meadows as Alice, the sketches proved popular with critics and viewers. As Kramden, Gleason played a frustrated bus driver with a battleaxe of a wife in harrowingly realistic arguments; when Meadows (who was 15 years younger than Kelton) took over the role after Kelton was blacklisted, the tone softened considerably.

When Gleason moved to CBS, Kelton was left behind; her name had been published in Red Channels, a book that listed and described reputed communists (and communist sympathizers) in television and radio, and the network did not want to hire her. Gleason reluctantly let her leave the cast, with a cover story for the media that she had "heart trouble". At first, he turned down Meadows as Kelton's replacement. Meadows wrote in her memoir that she slipped back to audition again and frumped herself up to convince Gleason that she could handle the role of a frustrated (but loving) working-class wife. Rounding out the cast, Joyce Randolph played Trixie, Ed Norton's wife. Elaine Stritch had played the role as a tall and attractive blonde in the first sketch but was quickly replaced by Randolph. Comedy writer Leonard Stern always felt The Honeymooners was more than sketch material and persuaded Gleason to make it into a full-hour-long episode.

In 1955, Gleason gambled on making it a separate series entirely. These are the "Classic 39" episodes, which finished 19th in the ratings for their only season. They were filmed with a new DuMont process, Electronicam. Like kinescopes, it preserved a live performance on film; unlike kinescopes (which were screenshots), the film was of higher quality and comparable to a motion picture. That turned out to be Gleason's most prescient move. A decade later, he aired the half-hour Honeymooners in syndicated reruns that began to build a loyal and growing audience, making the show a television icon. Its popularity was such that in 2000 a life-sized statue of Jackie Gleason, in uniform as bus driver Ralph Kramden, was installed outside the Port Authority Bus Terminal in New York City.

Gleason returned to the live format for 1956–57 with short and long versions, including hour-long musicals. These musical presentations were reprised ten years later, in color, with Sheila MacRae and Jane Keane as Alice and Trixie.

Audrey Meadows reappeared for one black-and-white remake of the '50s sketch "The Adoption", telecast January 8, 1966. Ten years later she rejoined Gleason and Carney (with Jane Kean replacing Joyce Randolph) for several TV specials (one special from 1973 was shelved).

The Jackie Gleason Show ended in June 1957. In 1959, Jackie discussed the possibility of bringing back The Honeymooners in new episodes. His dream was partially realized with a Kramden-Norton sketch on a CBS variety show in late 1960 and two more sketches on his new hour-long CBS show The American Scene Magazine in 1962.