171. Pharmacogenetics: Guiding Psychotropic Medication Rx
Discover some eye-opening exploration of genetics, medication choices, and evidence-based practices in pediatric psychiatry! Join host Dr. Lia Gaggino and guest Dr. Lisa Namerow as they navigate the intricate world of pharmacogenomic testing, the impact on prescribing behavior, and the crucial relevance of genetic panels for pediatric patients. From the evolving landscape of pharmacogenomics to the challenges of interpreting genetic findings, this discussion sheds light on the pivotal role of nonpharmacologic options and the need for validated guidelines in treating pediatric anxiety and depression. The conversation between Dr. Gaggino and Dr. Namerow has shed light on the challenges and opportunities associated with pharmacogenomic testing in pediatric psychiatry. With the complexity of interpreting results and the risk of inappropriate medication choices, the field faces a critical juncture in the responsible adoption and implementation of genetic information. However, the lack of clear guidelines and the risk of misinterpretation highlight the need for caution in prescribing decisions. As we navigate this landscape, it is essential for providers to prioritize the validation of guidelines and the responsible use of genetic information to ensure the safe and effective treatment of pediatric anxiety and depression. Together, we can work towards a future where genetic testing enhances the care of pediatric patients facing mental health challenges.
[00:33 -12:41] The Conundrum of Genetics in Psychiatry
[12:42 - 28:33] Understanding Clinical Pharmacogenetics
[28:34 - 33:05] Moving Beyond the Binning Concept in Data Analysis
[33:06 - 44:13] Utilizing Sequence to Script in Clinical Practice
[44:14 - 51:44] Closing segment Takeaway
Links to resources mentioned on the show
Sequence 2 Script: www.sequence2script.org
Pharmacogenomics: An Update for Child and Adolescent Psychiatry https://experts.umn.edu/en/publications/pharmacogenomics-an-update-for-child-and-adolescent-psychiatry
Editorial: Beyond Red Light Green Light: https://europepmc.org/article/med/34767918
Child Psychiatry Access Programs by state: https://www.nncpap.org/map
Other episodes you may like:
https://pediatricmeltdown.com/episodes
Ep 45 Pharmacogenomics: How Genetic Testing Can Help Us
Ep 44 Anxiety Disorders in Children: Treatment Pearls
Key quotes for Twitter:
"Given the current evidence base, consider pharmacogenetic testing. If the medication that you have determined through your evaluation and evidence-based review has relevant gene medication associations, then consider pharmacogenetics."... Dr. Lisa Namerow on The Future of Pharmacogenetics:
"We know that if we see a kid who's being treated with Des Venlafaxine or Pristiq for depression or anxiety, that patient has gotten pharmacogenetic testing."... Dr. Lisa Namerow on Pharmacogenetic Testing
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