Health & Fitness:Alternative Health
Angela welcomes Nichola Conlon to talk about the critical molecule NAD (Nicotinamide Adenine Dinucleotide) and its importance for the human body.
Nichola provides a comprehensive overview of NAD, highlighting its crucial roles in energy production within cells and as a signaling molecule for cellular maintenance and repair. Angela and Nichola also look into how NAD levels decline with age, impacting energy levels and cellular health, ultimately contributing to the aging process
KEY TAKEAWAYS
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NAD, or nicotinamide adenine dinucleotide, is a crucial molecule for energy production in cells and acts as a signaling molecule for cellular maintenance and repair.
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NAD levels decline with age, starting from birth, and this decline is linked to reduced energy levels and impaired cellular maintenance and repair, contributing to the aging process.
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Intermittent fasting, calorie restriction, and exercise are ways to positively impact NAD levels by creating an energy stress that activates the AMPK pathway, leading to increased NAD production.
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High-intensity interval training and fasting in a fasted state can further upregulate the AMPK pathway, enhancing the body's ability to produce NAD.
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The salvage pathway in cells is responsible for recycling NAD breakdown products, primarily nicotinamide, back into usable NAD. However, this pathway becomes dysregulated with age due to a decline in the enzyme NAMPT, leading to decreased NAD levels in older cells.
BEST MOMENTS
"NAD, I sometimes refer to it as probably the most important molecule that you've never heard of."
"From research that's been done, it seems like it declines from birth. So by the time you're age 20, you've kind of got half the amounts of NAD that you had when you were born."
"I think what's known is that any level of fasting really is going to start to actually increase your NAD levels."
"So all the beneficial effects of exercise, fasting, et cetera, are happening because they're increasing the ability of our cells to use this salvage pathway."
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Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine.
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