I talk about allele-specific expression: why it arises and how it can be reliably detected.
Sections:
The biology of allele-specific expression (2:17) Detecting allele-specific expression with RNA-seq (7:46) Mapping and sequencing biases (16:39) The experiment in yeast (19:47) Statistical models (21:44)Links:
A powerful and flexible statistical framework for testing hypotheses of allele-specific gene expression from RNA-seq data Supplemenal information Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data The talk by John Marioni The blog post explaining the RSEM model
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