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Paul Saladino MD podcast

Paul Saladino MD podcast

Health & Fitness:Medicine

29. Will eating an animal based diet over-activate mTOR?  With James Clement

29. Will eating an animal based diet over-activate mTOR? With James Clement

2020-01-14
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James W. Clement is a lawyer and entrepreneur turned research scientist who has devoted the last two decades to understanding the science of life extension. He is best known for his Supercentenarian Research Study, which he started in 2010 with Professor George M. Church of Harvard Medical School and has received international press coverage. Through worldwide scientific collaborations and in his own laboratory, James focuses on advancing cutting-edge biomedical discoveries. He is the founder of the nonprofit Betterhumans biomedical research organization. Led by a collection of high-profile researchers, the organization focuses on bringing cutting edge scientific discoveries from the lab to the clinic. Clement was the 12th person in the world to have his whole genome sequenced and is Personal Genome Project participant #145

 

Time Stamps:

10:10 Start of podcast 

10:50 What type of research is James doing and how does it relate to aging?

12:55 Compression of morbidity. 

23:50 Feedlot meat and processed foods (23:50-24:35)

25:50 Super centenarian studies.

28:25 Observations on what super centenarians have in common.

31:40 Laron Dwarfs and IGF1 (22:00-22:45)

33:30 Should we over stimulate IGF1?

37:10 Measuring IGF1

39:40 Blue Zones and centenarian diets

42:50 Intermittent Hypoxia 

46:40 Over fasting, finding a good balance.

51:40 Environmental hormesis 

52:50 Okinawans 

55:40 Confounding variables.

1:00:25 mTor/ketosis and glycogen depletion in the liver. 

1:03:40 Animal based diets and intermittent ketosis.

1:06:10 James' thoughts on the carnivore diet.

1:10:55 Lack of nutrients in a plant based diet.

1:12:30 Benefits of prolonged ketosis in morbidly obese.

1:16:10 Protein sparing modified fast benefits.

1:20:10 Calorie restricted pure vegan diet.

1:22:00 Dexa scan.

1:25:50 James's insulin levels.

1:27:40 AGEs (advanced glycation end products)

1:34:10 Stress and glucose levels.

1:38:50 Does too much protein harm the kidneys?

1:45:10 Protein cycling.

1:46:34 Occasional long term fasting benefits.

1:47:35 Loma Linda sperm quality.

1:49:40 Carnivore diet for longevity.

1:52:20 Issues with studies comparing meat eaters vs. non meat eaters.

1:54:00 The most radical thing James has done rece

view more

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182. Does red meat cause cancer?
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181. How to reverse high blood pressure
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180. How to lose weight
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179. Am I on TRT? August 2022 bloodwork update
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178. Statins: Should you take one for “elevated” LDL?
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177. Glyphosate: how it's harming you
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176. Danica Patrick: Breast implants ruined her health
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175. AMA: Glyphosate, Sunning your balls, and APOE4
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174. AMA: Randle cycle, Fruit and NAFLD, Contaminated Avocado oil/Olive oil, PFAs, Deer liver and Pregnancy
2022-08-01
173. Animal Based Vs Keto, A friendly debate with Thomas DeLauer
2022-07-25
172. Dangers of a keto diet
2022-07-18
171. July 2022 Bloodwork Review!
2022-07-12
170. How to fix your gut!
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169. Do cows cause climate change?
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168. Why I don't worry about my cholesterol
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167. Why I don't eat fish, chicken or pork!
2022-06-14
166. AMA (Ask me anything): Black seed oil, polyester clothes, carbohydrate cravings, constipation, and how to detox from seed oils...
2022-06-07
165. Are plant-based diets appropriate for children and pregnancy? With Ex-Vegan Jon Venus
2022-05-30
164. Dietary guidelines recommend meat/organs as the ideal first food for infants!
2022-05-23
163. Live AMA (Ask Me Anything) at the 2022 Animal Based Gathering
2022-05-16
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