Freely Filtered, a NephJC Podcast
Health & Fitness:Medicine
Freely Filtered 022: Uric Acid faces the Music.
The Filtrate:
Joel Topf
Swapnil Hiremath
Samira Farouk
And special guests:
Katalin Susztak, Professor of Medicine Perlman School of Medicine, University of Pennsylvania. @KSusztak
Show Notes:
CKD-FIX: Effects of Allopurinol on the Progression of Chronic Kidney Disease
PERL: Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes
Coverage at NephJC: Effects of Allopurinol on the Progression of Chronic Kidney Disease
Richard Johnson’s theory in pay-walled Nature Reviews Nephrology: Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome
Richard Johnson’s theory in open access Nehrology Dialysis and Transplantation: Uric acid and chronic kidney disease: which is chasing which?
PERL: Preventing early renal loss
Iohexol, good for measuring GFR as well as causing contrast associated nephropathy?
Uric acid versus urate: The Crystallization of Monosodium Urate
Association of HLA-B*5801 allele and allopurinol-induced Stevens Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis
WHO list of essential medications
Fixing the numbers, specifically phosphorous
GFR Decline as an End Point for Clinical Trials in CKD: A Scientific Workshop Sponsored by the National Kidney Foundation and the US Food and Drug Administration
Cost of allopurinol: $7/month but it is only $9 for 3 months
Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial
Tipping point analysis - multiple imputation for stress test under missing not at random (MNAR) or a YouTube video if that’s your speed (sorry, I couldn’t find a TikTok on imputation stress tests).
Mendelian randomization study of urate and CKD by Ron Do and team
Dad jokes
Fake systematic review by Johnson’s group showing Urate lowering prevented CKD
Hyperuricemia As a trigger of Immune Response in Hypertension and Chronic Kidney Disease by Claudio Ponticelli published the week after these two RCTs were published.
NEJM Editorial: Urate-Lowering Therapy and Chronic Kidney Disease Progression by Daniel Feig
COVID and PPI manuscript
Hashtag the cowboy
‘WhatsApp®’ening in nephrology training
Arkana LIVE Pathology Sessions
NephJC Summer Book Club. Read Rana Awdish’s In Shock
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