mTOR in Aging Ep5 - Diet & mTOR Dr Sabatini Interview Series

Dr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research.

He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex regulator of our metabolism

In this video Dr. Sabatini discusses how diet effects mTOR activation. He also talks about calorie restriction and intermittent fasting.

Some key references.

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf

Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/