How did the early colonists in Virginia know that they could profitably grow a species of tobacco from South America? They learned about it from the series of mostly short-lived English, French, and Dutch colonies and outposts in tropical South America, between the Amazon and Orinoco rivers, in the area called "Guiana." We discuss with historian Melissa Morris how these early colonies, despite being almost totally forgotten by historians, left a lasting imprint on the Americas, and reveal the haphazard and unpredictable nature of early global empires.
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