#43: oxycodone+acetaminophen (Percocet) | Treating Moderate to Severe Pain

Oxycodone+acetaminophen (APAP) is an analgesic combination product also known as Percocet. When dosing for Percocet one should consider also prescribing naloxone if there is a possible risk of opioid overdose or accidental ingestion. It is also very important to note that the lowest effective dose at the shortest effect duration should be used. Dosing for Percocet is based on the oxycodone component but limited by the APAP component. A general dosing range is 2.5-10 mg oxycodone PO q6h prn. Do not exceed 1 gram of APAP in 4 hours and 4 grams of APAP in 24 hours. There are a large amount of black box warnings and it is highly suggested to review them all. Some of note are for addiction/abuse/misuse, respiratory depression, and hepatotoxicity. Patients that should not use this medication are those with severe asthma or similar breathing problems, stomach or intestine blockage, drug or alcohol addiction, or problems with urination/thyroid/pancreas/gallbladder.

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