What happens if you run with a neuroma pad in the wrong place?

Just today I was seeing a runner during a house call and he had a neuroma. So, understandably, he put a neuroma pad in his shoes.

When he was running, his neuroma suddenly got way worse!

I asked him what happened.
 
He said, "I moved it a little bit. I moved it from where you put it before and I thought it would take more pressure off, but I think it actually made it worse and it really flared it up."
 
What happens if you run with a neuroma pad in the wrong place? 
 
Well, that's what we're talking about today on the Doc on the Run podcast.