Episode 28 - Development of Tapinarof and Treatment of Psoriasis | The Future of Dermatology Podcast

Summary

In this episode of the Future of Dermatology podcast, Dr. Farah Kamangar and Dr. Tina Bhutani discuss the mechanism of action of aryl hydrocarbon receptors (AHR) and its potential in dermatology. They explore the history of AHR and its connection to coal tar, as well as its role in inflammation, antioxidant activity, and metabolism. They also touch on the importance of considering the impact of circadian rhythms and sleep on skin health. The conversation highlights the potential of AHR-targeted therapies in achieving longer remissions and the need to view psoriasis patients as a whole, addressing comorbidities and environmental factors. The episode concludes with a discussion on the future of dermatology, including the possibility of directly targeting resident memory T cells and the further exploration of AHR mechanisms.

This episode is sponsored by an educational grant from the company Dermavant.

Takeaways

• Aryl hydrocarbon receptors (AHR) have a complex mechanism of action and can have anti-inflammatory, antioxidant, and metabolic effects.
• AHR-targeted therapies, such as tofacitinib, have shown promise in achieving longer remissions in psoriasis patients.
• Considering the impact of circadian rhythms and sleep on skin health is important, as sleep loss can increase inflammation and affect skin diseases.
• Psoriasis patients should be viewed as a whole, addressing comorbidities and environmental factors.
• The future of dermatology may involve directly targeting resident memory T cells and further exploring the mechanisms of AHR.
• AHR-targeted therapies may offer new possibilities for treating inflammatory skin diseases and achieving longer remissions.

Chapters

• 00:00 Introduction
• 02:24 Understanding the Mechanism of Action of Aryl Hydrocarbon Receptors
• 09:07 The Impact of Circadian Rhythms and Sleep on Skin Health
• 12:43 Viewing Psoriasis Patients as a Whole
• 16:39 The Potential of AHR-Targeted Therapies in Achieving Longer Remissions
• 22:35 Exploring the Mechanisms of Aryl Hydrocarbon Receptors