Cytochrome P450 2C9 and Coronary Resistance Vessel Tone

Understanding the underlying mechanisms of increased coronary blood flow during exercise is the pursuit of many cardiovascular researchers worldwide. Here, Associate Editor Masafumi Kitakaze interviews lead author Dirk Duncker (Erasmus University Medical Center) and expert Masaru Sugimachi (National Cardiovascular Center, Osaka) about the new study by Zhou et al on the vasodilator and vasoconstrictor metabolites produced by cytochrome P-450 (CYP) 2C9 in pigs both at rest and during exercise. Listen in to learn how Duncker and colleagues used innovative in vivo and in vitro experimental conditions, achieving surprisingly different results related to the effects of sulfaphenazole in the presence of combined NOS/COX blockade.

Zhichao Zhou, Veemal Hemradj, Vincent J. de Beer, Fen Gao, Maaike Hoekstra, Daphne Merkus, and Dirk J. Duncker Cytochrome P-450 2C9 exerts a vasoconstrictor influence on coronary resistance vessels in swine at rest and during exercise Am J Physiol Heart Circ Physiol, published online February 3, 2012, doi:10.1152/ajpheart.00648.2011.