The Role of EETs in Pressure-induced Vasoconstriction

What’s new in skeletal muscle arteries? Research by Sun et al demonstrates, for the first time, metabolic regulation of myogenic tone in a skeletal muscle small resistance artery by EETs. Listen as Associate Editor Mordy Blaustein interviews lead author An Huang (New York Medical College) and expert David Harder (Medical College of Wisconsin) about this innovative knock-out mouse model, responses of different types of vascular beds to various vasodilatory agents, and the importance of basic studies on SEH inhibitors as the backbone of clinical trials.

Dong Sun, Azita J. Cuevas, Katherine Gotlinger, Sung Hee Hwang, Bruce D. Hammock, Michal L. Schwartzman, An Huang Soluble epoxide hydrolase-dependent regulation of myogenic response and blood pressure Am J Physiol Heart Circ Physiol, published April 15, 2014. DOI: 10.1152/ajpheart.00920.2013.