In this podcast we highlight the recent study by Domeier and colleagues, which looked for a way to pharmacologically restore proper function of the ryanodine receptor with advancing age. Did they find it? Editor in Chief Dr. Irving Zucker interviews lead author Timothy Domeier (The University of Missouri School of Medicine) and expert Eric Sobie (Mount Sinai School of Medicine) about this fascinating study investigating whether ryanodine receptor mediated calcium release in the aged heart was altered by dantrolene. In fact, Domeier and colleagues did find that dantrolene provided a protective effect against pro-arrhythmic calcium sparks and calcium waves in diastole. Hear about this finding and much more by clicking play below.
Timothy L. Domeier, Cale J. Roberts, Anne K. Gibson, Laurin M. Hanft, Kerry S. McDonald, Steven S. Segal Dantrolene suppresses spontaneous Ca2+ release without altering excitation-contraction coupling in cardiomyocytes of aged mice Am J Physiol Heart Circ Physiol, published September 15, 2014. DOI: 10.1152/ajpheart.00287.2014.
More Episodes
2024-10-10
130
2024-09-12
137
2024-08-06
221
2024-06-04
190
2024-05-03
239
2024-03-18
231
2024-03-11
209
2024-02-27
211
2024-01-12
264
2023-12-07
332
2023-11-28
329
2023-11-08
324
2023-10-02
756
2023-08-10
452
2023-07-31
366
2023-07-24
343
Get this podcast on your
phone, FREE
