The group began Conference Ten, the high point of Cassian teaching on imageless and unceasing prayer. Cassian sets the stage by seeking to put the notion of imageless prayer in highest possible relief through giving an account of the monk Serapion's fall into the anthropromorphite heresy. Serapion's mind becomes cluttered with the erroneous and deadly image of a God with human contours; unable to let go of the confines of what the imagination and intellect can construct to be drawn by faith into the intimacy and mystery of the Triune God. It is through the pathos of this story that Cassian brings his readers to see the beauty of pure prayer and the unbroken communion with God it promises. When such prayer is attained, everything a person does is God. And this, which is the end of all perfection, is equivalent to transforming one's whole life into a single and continuous prayer.
A lengthy discussion then ensued regarding the simplicity of life that must be fostered in order for the silence of solitude to emerge in which such unceasing prayer can take place. The group considered the types of pseudo contemplation that have arisen in the modern culture that sadly make genuine prayer more and more unlikely.