BRS-3 Regulation of Blood Pressure and Heart Rate

Just what are the contributions of bombesin-like receptor 3 to blood pressure regulation? Listen as Associate Editor Debra I. Diz (Wake Forest University School of Medicine) interviews lead author Marc Reitman (National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health) and content expert Amy C. Arnold (Vanderbilt University) about the work by Lateef et al., which combined the use of genetic tools—a BRS-3 knockout mouse—as well as pharmacologic tools to explore the effect of this orphan receptor on blood pressure, filling a void in the literature about the physiology of BRS-3. This podcast tackles just about everything: “uncooperative” mice, effects on baroreflex sensitivity, and the controversial subject of pharmacological interventions for the treatment of obesity. Does the absence of evidence equate to “the evidence of absence”? Listen and find out.

Dalya M. Lateef, Cuiying Xiao, Robert J. Brychta, André Diedrich, Jurgen Schnermann, Marc L. Reitman Bombesin-Like Receptor 3 Regulates Blood Pressure and Heart Rate via a Central Sympathetic Mechanism Am J Physiol Heart Circ Physiol, published online January 22, 2016, DOI: 10.1152/ajpheart.00963.2015.