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About This Episode:
It has been clearly demonstrated that elevated LDL-cholesterol (LDL-C), or perhaps more specifically pro-atherogenic lipoproteins, is causal in atherosclerosis development in humans.
One crucial concept within this is that the risk relates not only to the magnitude of elevated LDL-C, but the duration of exposure. Thus, the role of LDL-C in driving atherosclerosis is referred to as a “cumulative, integrated exposure over the lifecourse”.
But, what exactly does this mean?
In this episode, Danny discusses the cumulative exposure model of LDL-C in atherosclerosis, the evidence supporting it, and the implications of this for the “debates” that get raised in relation to LDL-C (or apoB-containing lipoproteins) and heart disease.
Links:
#314: Q&A – Hemochromatosis, Sodium, Bone Health, & More!
#313: Fergus Connolly, PhD – Authenticity, Elite Human Performance & Getting the Best From Others
#312: Allison Brager – Sleep Architecture, Chronotypes & Rescuing Performance
#311: Andrew Chappell, PhD – Diet Strategies in Elite Natural Bodybuilders
#310: Meeta Singh, MD – Sleep & Circadian Disruption in Pro Athletes: Dealing With the NBA Schedule
#309: Ciaran O’ Regan – Epistemology, Ignorance Navigation & the Error-Correcting Machinery of Science
#308: Robin Tucker, PhD, RD – Impact of Sleep on Taste Perception, Cravings & Food Reward
#307: Stephan Guyenet, PhD – Are Popular Nutrition & Health Books Trustworthy, Accurate & Health-Promoting?
#306: Daniel Davey – Food Preparation Skills, Being an Effective Nutritionist & Creativity
#305: John Berardi, PhD - Be a "Change Maker" in your Health & Fitness Career
#304: Tommy Wood, MD, PhD – Neurodegenerative Disease, Traumatic Brain Injury & Genetics
#303: Brad Dieter, PhD - How Do We Tackle Type 2 Diabetes & Lifestyle-related Chronic Disease?
#302: Leonie Heilbronn, PhD – Alternate-Day Fasting, Early Time-Restricted Feeding & Caloric Restriction
#301: John Berardi, PhD - Tribalism in Nutrition
#300: The Random Episode
#299: Mark Hopkins, PhD – Compensatory Eating, Exercise-induced Weight Loss & Energy Balance Homeostasis
#298: David Zeevi, PhD – Genes of Gut Microbes & Inter-Individual Variation in Glucose Response
#297: Cliff Harvey, PhD – Carbohydrate-Restriction, Ketosis & Neuroprotection
#296: Alan Flanagan – Circadian Entrainment, Chronotypes & Chrononutrition
#295: Ben House, PhD – How Much of a Surplus Do Advanced Lifters Need for Optimal Muscle Gain?
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