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About This Episode:
It has been clearly demonstrated that elevated LDL-cholesterol (LDL-C), or perhaps more specifically pro-atherogenic lipoproteins, is causal in atherosclerosis development in humans.
One crucial concept within this is that the risk relates not only to the magnitude of elevated LDL-C, but the duration of exposure. Thus, the role of LDL-C in driving atherosclerosis is referred to as a “cumulative, integrated exposure over the lifecourse”.
But, what exactly does this mean?
In this episode, Danny discusses the cumulative exposure model of LDL-C in atherosclerosis, the evidence supporting it, and the implications of this for the “debates” that get raised in relation to LDL-C (or apoB-containing lipoproteins) and heart disease.
Links:
#274: James Lindsay, PhD - When Peer-Review Goes Wrong
#273: Bryan Chung, MD, PhD – Dealing with Science Overwhelm & Improving Your Relationship with Research
#272: Barbora de Courten, PhD – Effect of Carnosine on Glucose Metabolism and Chronic Disease Risk
#271: Prof. John Hawley – Circadian Metabolomics & Time-Restricted Feeding
#270: Alexander Kolliari-Turner – Anabolic Steroids, Muscle Memory & Advances in Drug Testing
#269: Lyndon Purcell & Jacob Schepis: Physiology, Hypertrophy & Discussions
#268: Luke Leaman - Physiology, Nutrition From First Principles & Prioritising Health
#267: Fiona Willer, AdvAPD - Health At Every Size, Non-Dieting & Weight-Neutral Approaches
#266: Marty Kendall - Nutrient Optimiser, High-Satiety Diets & Carb/Fat Combinations
#265: Lessons From Experts - Prediabetes, Autophagy, Relative Energy Deficiency and Carbohydrate Periodization
#264: Prof. Michael Ristow – Longevity, Mitochondria & Free Radicals
#263: Brenda Davy, PhD – Dietary Assessement Methods in Nutrition Research
#262: Trevor Kashey, PhD – Thoughts on Science, Learning & Nutrition Practice
#261: Ari Snaevarsson – Eating Disorder Recovery, Body Positivity & Intuitive Eating
#260: Steve Taylor, RD - Sustainable Results, Human Behaviour & Dietary Approaches
#259: Chad Kerksick, PhD - Energy Availability and Pre-Exercise Protein vs. Fasted Training
SNR #258: Dan Garner – Building an Online Business as a Nutrition Coach
SNR #257: Andrew Jagim, PhD – Pre-Workout Supplementation: Current Evidence & Recommendations
SNR #256: Alex Leaf – Risks of High-Protein Diets?: Longevity, Gut Health & Microbiota
SNR #255: Alan Flanagan – Public Health Nutrition & the Role of Epidemiology
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